Metabolomix+

The Metabolomix+ is a unique combination of nutritional tests that provides an analysis of key nutritional biomarkers. A first morning void (FMV) urine collection, with optional add-on bloodspot finger stick and buccal swab, the Metabolomix+ nutritional test is a non-invasive, patient-friendly way to assess the functional need for antioxidants, B-vitamins, minerals, digestive support, fatty acids, and amino acids. Insights gained from the Metabolomix+ nutritional test allows clinicians to target nutritional therapies to the precise needs of their patients.

Additional markers are available for an even greater overview of a patient's nutritional status with easy to add modules based on a patient's unique needs.

What is a functional nutritional assessment?

Marked accumulation of organic acids in urine can signal a metabolic inhibition or block. The metabolic block may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up, or drug effect.

Enzymes that are responsible for metabolising organic acids are vitamin and mineral dependent. With this, elevations in organic acids can reflect a functional need for these nutrients on a cellular and biochemical level, even despite normal serum levels.1-5Recommendations for nutrient supplementation based on elevated organic acid results are generated using a literature-based proprietary algorithm.

Which patients might benefit from functional nutritional testing?

Common clinical indications for testing include:

• Mood Disorders6,7

• Mitochondrial Dysfunction8

• Fatigue9

• Chronic Stress10

• Inflammation11

Several diseases are associated with abnormal organic acid, amino acid, and fatty acid levels such as depression, anxiety, cardiovascular disease, neurocognitive decline, diabetes, cancer, anorexia, and many others.12-15

About the Metabolomix+ Profile

The Metabolomix+ Profile report allows for easy interpretation and clinically actionable results. It includes a Suggested Supplement Schedule that provides personalised recommendations based on test results. The Interpretation-At-A-Glance section of the report provides facts related to nutrient function, causes and complications of their deficiencies, and dietary sources.

The Metabolomix+ Profile report categorizes results into several metabolic areas:

• Organic Acids

  • Malabsorption and Dysbiosis

  • Cellular Energy and Mitochondrial Metabolites

  • Neurotransmitter Metabolites

  • Vitamin Markers

  • Toxin and Detoxification Markers

  • Tyrosine Metabolism

• Amino Acids

  • Nutritionally Essential Amino Acids

  • Nonessential Protein Amino Acids

  • Intermediary Metabolites

  • Dietary Peptide Related Markers

• Oxidative Stress Markers

• Essential and Metabolic Fatty Acids - Bloodspot (if selected as add-on profile)

  • Omega 3 Fatty Acids

  • Omega 6 Fatty Acids

  • Omega 9 Fatty Acids

  • Saturated Fatty Acids

  • Monounsaturated Fatty Acids

  • Delta-6 Desaturase Activity

  • Cardiovascular Risk

• Nutrient and Toxic Elements (if selected as add-on profile)

• Genomics (if one or more of the following SNPs are selected as add-ons)

  • APO E (C112R + R158C)

  • MTHFR Combined (A1298C + C677T)

  • TNF-α

  • COMT (V158M)

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